Long-term stability of the anti-influenza A compounds—amantadine and rimantadine
Identifieur interne : 001B00 ( Main/Exploration ); précédent : 001A99; suivant : 001B01Long-term stability of the anti-influenza A compounds—amantadine and rimantadine
Auteurs : Christoph Scholtissek [États-Unis] ; Robert G. Webster [États-Unis]Source :
- Antiviral Research [ 0166-3542 ] ; 1998.
English descriptors
- KwdEn :
- Teeft :
- Amantadine, Amantadine hydrochloride, Antiviral activity, Channel activity, Compounds amantadine, Drug preparations, Elsevier science, Forest pharmaceuticals, Giessen, Hydrochloride, Jude research hospital, Plaque, Plaque formation, Rimantadine, Rimantadine hydrochloride, Room temperature, Webster anti6iral research.
Abstract
Abstract: Amantadine and rimantadine hydrochloride were tested for stability after storage at different temperatures and under different conditions for extended periods of time. Both compounds were quite stable after storage for at least 25 years at ambient temperature; they both retained full antiviral activity after long-term storage or after boiling and holding at 65–85°C for several days. Thus, amantadine and rimantadine could be synthesized in large quantities and stored for at least one generation without loss of activity in preparation for the next influenza A pandemic in humans.
Url:
DOI: 10.1016/S0166-3542(98)00015-1
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000244
- to stream Istex, to step Curation: 000244
- to stream Istex, to step Checkpoint: 000895
- to stream Main, to step Merge: 001B55
- to stream Main, to step Curation: 001B00
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Long-term stability of the anti-influenza A compounds—amantadine and rimantadine</title><author><name sortKey="Scholtissek, Christoph" sort="Scholtissek, Christoph" uniqKey="Scholtissek C" first="Christoph" last="Scholtissek">Christoph Scholtissek</name></author><author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G" last="Webster">Robert G. Webster</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B10FB66A27914B132AE647C094BB6970C7A5EF9F</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S0166-3542(98)00015-1</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-PBSVFZWR-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000244</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000244</idno><idno type="wicri:Area/Istex/Curation">000244</idno><idno type="wicri:Area/Istex/Checkpoint">000895</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000895</idno><idno type="wicri:doubleKey">0166-3542:1998:Scholtissek C:long:term:stability</idno><idno type="wicri:Area/Main/Merge">001B55</idno><idno type="wicri:Area/Main/Curation">001B00</idno><idno type="wicri:Area/Main/Exploration">001B00</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Long-term stability of the anti-influenza A compounds—amantadine and rimantadine</title><author><name sortKey="Scholtissek, Christoph" sort="Scholtissek, Christoph" uniqKey="Scholtissek C" first="Christoph" last="Scholtissek">Christoph Scholtissek</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 N. Lauderdale, P.O. Box 318, Memphis, TN 38101</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G" last="Webster">Robert G. Webster</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Virology and Molecular Biology, St. Jude Children's Research Hospital, 332 N. Lauderdale, P.O. Box 318, Memphis, TN 38101</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Antiviral Research</title><title level="j" type="abbrev">AVR</title><idno type="ISSN">0166-3542</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">38</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="213">213</biblScope><biblScope unit="page" to="215">215</biblScope></imprint><idno type="ISSN">0166-3542</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0166-3542</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amantadine</term><term>Anti-influenza compounds</term><term>Rimantadine</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Amantadine</term><term>Amantadine hydrochloride</term><term>Antiviral activity</term><term>Channel activity</term><term>Compounds amantadine</term><term>Drug preparations</term><term>Elsevier science</term><term>Forest pharmaceuticals</term><term>Giessen</term><term>Hydrochloride</term><term>Jude research hospital</term><term>Plaque</term><term>Plaque formation</term><term>Rimantadine</term><term>Rimantadine hydrochloride</term><term>Room temperature</term><term>Webster anti6iral research</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Amantadine and rimantadine hydrochloride were tested for stability after storage at different temperatures and under different conditions for extended periods of time. Both compounds were quite stable after storage for at least 25 years at ambient temperature; they both retained full antiviral activity after long-term storage or after boiling and holding at 65–85°C for several days. Thus, amantadine and rimantadine could be synthesized in large quantities and stored for at least one generation without loss of activity in preparation for the next influenza A pandemic in humans.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Scholtissek, Christoph" sort="Scholtissek, Christoph" uniqKey="Scholtissek C" first="Christoph" last="Scholtissek">Christoph Scholtissek</name></region><name sortKey="Webster, Robert G" sort="Webster, Robert G" uniqKey="Webster R" first="Robert G" last="Webster">Robert G. Webster</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B00 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B00 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B10FB66A27914B132AE647C094BB6970C7A5EF9F
|texte= Long-term stability of the anti-influenza A compounds—amantadine and rimantadine
}}
| This area was generated with Dilib version V0.6.33. |  |